Therapeutic potential for enhancing NAD+ in aging and age-related diseases

Fatigue, memory loss, cardiovascular disease, diabetes… are diseases that we often encounter in the elderly. Although modern medicine has made many advances, finding effective treatments for these diseases remains challenging. However, a new ray of hope has emerged with the advent of research on NAD+. Much scientific evidence shows that increasing NAD in the body can help improve disease symptoms and prolong life.

1. Recent advances in the role of NAD+ in aging

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that plays a central role in cellular energy metabolism. In recent years, research has increasingly focused on exploring the important role of NAD+ in aging and age-related diseases.

• NAD+ and sirtuins: The connection between NAD+ and sirtuin proteins has been further clarified. Sirtuins act as cell “guardians”, helping to repair DNA, reduce inflammation and increase resistance to stress. NAD+ acts as a cofactor for sirtuin enzymes, activating their activity.
• NAD+ and mitochondria: NAD+ plays an important role in the energy production process in mitochondria. When NAD+ levels decrease, mitochondrial function is impaired, leading to increased free radical production and cell damage.
• NAD+ and age-related diseases: Studies have shown that reduced NAD+ levels are associated with many age-related diseases such as Alzheimer’s, Parkinson’s, type 2 diabetes and cardiovascular diseases.
• NAD+ and longevity: Animal research shows that enhancing NAD+ levels can prolong life and improve overall health.

2. Other methods to regulate NAD+

In addition to supplementing NAD+ precursors such as NMN and NR, there are several other methods that can be considered to regulate NAD+ levels in the body. However, it should be noted that the effectiveness of these methods is still being researched and there are no final conclusions.

2.1 Diet

• Foods rich in NAD+: Some foods contain naturally high amounts of NAD+, including poultry, fish, mushrooms, milk and nuts.
• Foods rich in NAD+ precursors: Foods rich in tryptophan (an amino acid needed to synthesize NAD+) such as turkey, pumpkin seeds, and milk can also help increase NAD+.
• Limit sugar and fat: Consuming too much sugar and fat can reduce NAD+ levels.

2.2 Exercise

• High-intensity interval training (HIIT): Studies show that HIIT can stimulate NAD+ production in muscles.
• Strength training: Strength training can also contribute to increased NAD+ levels.

2.3 Stress control

• Meditation: Meditation and other relaxation methods can help reduce oxidative stress, thereby protecting NAD+ and related enzymes.
• Get enough sleep: Getting enough sleep is important for the body to recover and produce NAD+.

2.4 Avoid contact with toxic substances

• Environmental pollution: Exposure to environmental pollutants can reduce NAD+ levels.
• Smoking: Smoking significantly reduces NAD+ levels in the body.

2.5 Other therapies

• Use plant compounds: Some plant compounds may have the effect of increasing NAD+ or activating sirtuin enzymes. However, more research is needed to determine the effectiveness and safety of these compounds.
• Light therapy: Some studies show that exposure to sunlight can stimulate NAD+ production.

3. Points to note when treating NAD+ enhancement

Job enhance NAD is being considered as a potential method to improve health old age disease and anti-aging. However, before deciding to use any method, you need to keep in mind some important points:

3.1 Expert advice

• Doctor: Always consult your doctor before starting any treatment, especially if you are taking other medications or have a medical history.
• Nutritionist: A nutritionist can advise on a suitable diet to naturally increase NAD+.

3.2 Personal effectiveness

• Individual differences: The effectiveness of increasing NAD+ can vary from person to person, so be patient and monitor results.
• Drug interactions: NAD+ can interact with some medications, so tell your doctor about all the medications you are taking.

3.3 Safety and side effects

• Limited research: Despite promising research, studies on NAD+ are limited, especially in humans.
• Side effects: Some people may experience side effects such as headaches, fatigue, and nausea when using NAD+ supplements.

3.4 Product quality

• Clear origin: Choose products from reputable brands and with clear origins.
• Quality testing: Products should be quality tested and guaranteed to not contain toxic substances.

3.5 Enhancement method

• Supplement: Supplementing NAD+ precursors such as NMN, NR is the most common way.
• NAD+ infusion: This method requires high technology and should only be performed at reputable medical facilities.
• Diet and lifestyle: Changing your diet, exercising regularly and reducing stress are also effective ways to increase NAD+.

3.7 Potential for abuse

• Excessive advertising: Be wary of excessive advertising about the effectiveness of NAD+.
• There is no miracle: There is no method that can completely rejuvenate the body.

In summary, NAD enhancement is a promising area of ​​research, but more research is needed to clarify its effects and applications. Before deciding to use any method for aging-related diseases, you should consult with medical professionals and carefully consider the benefits and risks.

Source: sciencedirect.com – sciencedirect.com – springer.com