What Are the Effects of NMN on the Skeletal System?

Nicotinamide mononucleotide (NMN), a precursor of NAD+, plays a vital role in improving health and slowing the aging process. Furthermore, numerous studies have demonstrated the role of NMN in musculoskeletal health. Let’s explore whether NMN is beneficial for the bones and joints and how to use NMN for musculoskeletal health in the following article.

1. What Are the Effects of NMN on the Skeletal System?

Today, many people are aware of the benefits of NMN for improving health and preventing aging. So, is NMN good for the bones and joints? Can using NMN help strengthen bones? Below are some benefits of NMN for musculoskeletal health:

1.1. Rejuvenation of Bone Cells

Like other organs, our bones are made up of living cells. Thus, old and damaged bone is continuously replaced by new bone. However, as we age, there are fewer bone-forming cells, partly because normal bone-forming cells become senescent. Senescent cells (which may accelerate the aging process in general) cannot form new bone, contributing to osteoporosis.

However, studies have found that NMN increases the number of mature bone cells, indicating that NMN promotes bone formation. Previous animal studies have shown that NMN can enhance the bone formation process. It seems to act in several ways, including rejuvenating bone stem cells, which are essential for bone formation. Although no studies have demonstrated that NMN promotes bone formation in patients with osteoporosis, NMN may potentially prevent age-related bone loss.

1.2. Enhancing Cartilage Regeneration

Some studies have shown that exogenous NMN supplementation enhances the formation of scar cartilage by increasing the total levels of NAD+ in the tissue. Furthermore, researchers found that the observed increase in cartilage components was due to the regenerative potential of heterogeneous stem cells activated by NMN. They emphasized the relationship between NAD+ and the regenerative capability of stem cells in the bone healing process, paving the way for the development of NMN as a potential treatment for fractures and even osteoporosis.

1.3. Increasing Bone Density

NMN has been demonstrated to support healthy bones and prevent osteoporosis by increasing the mineral density of bones through its ability to enhance collagen synthesis. NMN may also help increase calcium absorption and reduce inflammation in the bones, promoting stronger and healthier bones. Studies have shown that using NMN can also reduce risk factors for osteoporosis, such as age-related bone loss and decreased muscle mass.

1.4. Enhancing Muscle Strength

Some studies have found that NMN supplementation improves endurance in amateur runners. Researchers suggest that NMN enhances oxygen delivery to muscle tissues, providing additional energy to cells that are energy-depleted from exercise. This contributes to increased muscle strength.

2. Who Should Use NMN to Support Joint Health?

Supplementing with NMN is a way to help strengthen joint health that you can apply. NMN can be beneficial for many groups of people, but here are some individuals who should consider using NMN for joint health to improve bone health and enhance muscle strength:

• Elderly Individuals: As age increases, NAD+ levels in the body decrease, leading to impaired bone and cartilage function. NMN may help improve joint health in this age group.
• Individuals with Joint Issues: Those suffering from conditions such as arthritis, osteoarthritis, or osteoporosis may benefit from NMN’s anti-inflammatory and cell regeneration effects.
• Athletes or Regular Exercisers: NMN can support muscle recovery and improve strength, helping athletes maintain joint health and reduce the risk of injury.
• Individuals with Nutritional Deficiencies: People who do not get enough essential vitamins and minerals for bone health may consider supplementing with NMN to support bone regeneration and maintenance.
• Sedentary Individuals: Those who do not engage in regular physical activity may need NMN to enhance cellular function and support joint health.

Before starting NMN supplementation, it is advisable to consult a doctor or healthcare professional to ensure that this product is suitable for your individual health condition.

3. Considerations When Using NMN for Joint Health

One of the ways to help ensure healthy joints is to supplement with NMN daily through your diet or other methods. While using NMN, you should pay attention to the following issues:

• Studies have found health benefits with doses as low as 250 mg of NMN daily, with a maximum of 1,200 mg per day.
• Choose NMN products from reputable sources to ensure quality and effectiveness.
• NMN is also found in many foods, including avocados, cabbage, broccoli, tomatoes, and raw beef.
• Before adding any supplements to your diet, it’s important to discuss your specific condition with a doctor, along with any potential risks and benefits you should consider when using NMN for joint health.
• If you experience musculoskeletal issues, you should seek out appropriate solutions for early treatment. Additionally, proactively taking care of your health from an early age will help you live healthily, mentally sharp, and longer.

Source: https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage#Takeaway

The article has provided insights into the role of NMN in musculoskeletal health as well as the groups that should consider supplementing with NMN to improve overall health and prevent joint diseases and aging of the joints. Taking proactive care of your joint health early on will help you lead a healthier and longer life.

References: Healthline.com, Pmc.ncbi.nlm.nih.gov, Nmn.com